MRSA Gene Hunt
This is a classroom-based activity from the Wellcome Trust Sanger Institute that allows students to explore the features of two bacterial pathogen genomes. The aim of the activity is to highlight the role of different genetic components in two strains of Staphylococcus aureus and to identify how these have led to one strain becoming…
Build a Bug Activity
This is a classroom-based activity from the Wellcome Trust Sanger Institute that allows students to explore the features of two bacterial pathogen genomes. The aim of this activity is to highlight the role of different genetic components in two closely related subspecies of Salmonella enterica, and to identify how these contribute…
DNA Sequencing
From the Wellcome Trust Sanger Institute, this animation shows a detailed overview of the processes involved in the dideoxy or Sanger method for sequencing DNA. This is the method used to sequence the human genome. The animation demonstrates the principles and techniques involved in the Sanger sequencing method, and how the technology…
How the Human Genome Was Sequenced
From the Wellcome Trust Sanger Institute, this resource introduces the Human Genome Project (HGP). A short animation gives: • an introduction to DNA and genomes; • an overview of which countries were involved in the international Human Genome Project; • a description of the processes, biological principles and…
DNA Libraries: Subcloning
From the Wellcome Trust Sanger Institute, these materials contain a short animation demonstrating the process of subcloning, which is one of the stages involved in sequencing the genome of a large organism. Subcloning is the process of breaking up BAC clones (fragments of DNA inserted into bacterial cells) into smaller more manageable…
DNA Libraries: Bacterial Artificial Chromosome (BAC)
Produced by the Wellcome Trust Sanger Institute, this resource contains an overview of the techniques involved in making a BAC (Bacterial Artificial Chromosome) library. It consists of an animation that covers the key stages in the process: • Extracting DNA from white blood cells and use of restriction enzymes to "cut…